Specialists in multiple sclerosis imaging for clinical trials

About us

Queen Square Analytics (QSA) provides imaging services and analytics for neurological clinical trials, with a focus on multiple sclerosis (MS). Our team brings decades of experience in MS clinical trials and neurodegenerative disease.

Our story

From reading films to automated, auditable imaging

QSA's roots are in the MRI research unit at the UCL Queen Square Institute of Neurology, which has managed and analysed MS clinical trial imaging since the 1990s. Reading scans once meant examining films by hand. Today MRI is routine and image processing has advanced rapidly.

QSA combines UCL's expertise in medical imaging with industrial-grade services that automate image receipt, processing and quality control, with a full audit trail. QSA was incorporated in January 2020 as a UCL spin-out, supported by UCL Business (UCLB).

People

Leadership and team

Leadership and board

Advisors

Team

Technology

Subtyping MS by biology, not by symptoms

Around 2.8 million people worldwide live with multiple sclerosis (Atlas of MS, 2020), and it often causes disability early in adult life. Clinicians classify MS by its clinical course, but the clinical course does not map neatly onto the underlying disease biology. Treatments chosen on symptoms and course alone may therefore miss the mechanisms that drive the disease. Measurable markers from brain images and blood reflect that biology more directly.

Large datasets and artificial intelligence now make it possible to find patterns that could not be detected before. QSA applies AI to imaging and blood measures to define data-driven MS subtypes and stages. Changes on MRI and in blood biomarkers can come before clinical worsening, so these subtypes may help identify patients at higher risk of disability progression. QSA works with data from clinical trials, observational cohorts and routine clinical care. The aim is to improve how patients are selected for clinical trials and, in future, to help clinicians choose the most suitable therapy for each patient.

History

Three decades of MS imaging at UCL

  1. 1992MS clinical trials office established at Queen Square (beta-interferon study)
  2. 2018Subtype and Stage Inference (SuStaIn) machine-learning method published in Nature Communications
  3. 2020Queen Square Analytics incorporated as a UCL spin-out
  4. 2021New MS subtypes identified with SuStaIn, published in Nature Communications
  5. 2023Partnership with Bioxydyn for neurological clinical trials
  6. 2025Two biological MS subtypes identified from MRI and a blood biomarker, published in Brain

Recognition

Programmes and awards

2021–22 cohort

KQ Labs

Selected for the Francis Crick Institute accelerator programme.

2021 cohort

Digital Catapult

Selected for the Machine Intelligence Garage programme.

2021–22

Royal Society

Entrepreneur in Residence at UCL awarded to Bruce Lynn.

2021

Innovate UK

Innovate UK Scholar award to Daniele Ravì.

Planning a neurology trial?

Tell us about your study and the imaging questions behind it.

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